Phone (336) 292-1510
Fax (336) 292-0679

Receive our eNewsletter

  Home  
  Our Team  
  Patient Info  
  Services  

News for Healthier Living

Metabolic Shift in Liver Cancer: How PDHX Acetylation Drives Tumor Growth

A recent study has unveiled a new mechanism driving hepatocellular carcinoma (HCC) progression through the acetylation of pyruvate dehydrogenase complex (PDC) component X (PDHX), a critical component of the PDC. This modification disrupts PDC assembly, inhibits its function, and shifts metabolism towards aerobic glycolysis, promoting tumor growth. The findings highlight PDHX acetylation as both a potential biomarker and therapeutic target, offering new possibilities for liver cancer treatment and advancing our understanding of cancer cell metabolism.

March 3, 2025


March 13 2025

March 12 2025

March 11 2025

March 10 2025

March 9 2025

March 8 2025

March 7 2025

March 6 2025

March 5 2025

March 4 2025

March 3 2025

March 2 2025

February 28 2025